Domaine de la Romanée Conti is co-owned by the de Villaine and Leroy/Roch families, the former successors to Jacques-Marie Duvault-Blochet who bought the vineyard of La Romanée Conti in 1869, the latter since acquiring the shares of other descendants of Duvault-Blochet in 1942. The Domaine is today run by Aubert de Villaine. Many people in Burgundy just refer to 'DRC' as "the Domaine".

The Domaine has 25 hectares of vineyards, all Grand Crus. As well as the 1.8-hectare monopole La Romanée Conti, the Domaine purchased its other monopole, La Tâche, in 1933, along with significant holdings in the grand crus of Richebourg, Romanée-St-Vivant, Grands Échezeaux, Échezeaux, and Le Montrachet at various points in the 19th and 20th centuries. The Domaine is the largest owner of each of the red wine grand crus.