The Riserva is produced from the Greppo Estate Sangiovese vineyards of over 25 years of age and is made only in exceptionally good years. The Riserva is aged 36 months in Slavonian oak casks. The basic characteristic of the Brunello of Greppo Biondi Santi is its longevity, even over a hundred years. To allow the flavour to fully unfold, the bottle should be opened and a bit of wine poured out at least 8 hours before drinking.

Biondi Santi remains a beacon for traditionally made Rosso and Brunello. The Biondi-Santi wines are more approachable young than they used to be, but little else appears to have changed.